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Phosphoribosyl-AMP cyclohydrolase : ウィキペディア英語版 | Phosphoribosyl-AMP cyclohydrolase
In enzymology, a phosphoribosyl-AMP cyclohydrolase () is an enzyme that catalyzes the chemical reaction :1-(5-phosphoribosyl)-AMP + H2O 1-(5-phosphoribosyl)-5-(phosphoribosylamino)methylideneamino )imidazole-4-carboxamide Thus, the two substrates of this enzyme are 1-(5-phosphoribosyl)-AMP and H2O, whereas its two products are phosphoribosylamino)methylideneamino]imidazole-4-carboxamide. This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is 1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase. Other names in common use include PRAMP-cyclohydrolase, and phosphoribosyladenosine monophosphate cyclohydrolase. This enzyme participates in histidine metabolism. ==Structural studies==
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .
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